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Symptoms of intoxication: The following side effects mostly occur to an increased extent as a consequence of overdose: Nausea, vomiting, diarrhoea, severe mucositis, ulcerations and hemorrhages in the gastrointestinal tract, myelosuppression (thrombocytopenia, leukopenia, agranulocytosis).
Therapy of intoxication: If symptoms of intoxication occur, administration of fluorouracil should be discontinued immediately. Symptomatic therapeutic measures are to be initiated.
Pronounced myelosuppression must be treated under inpatient conditions. It involves - if necessary - substitution of missing blood components and antibiotic therapy. Transfer of the patient into an aseptic room may become necessary.
No specific antidote is available.
Haematological monitoring should be performed up to 4 weeks after overdose.
